The School of Arts & Sciences

Department of Natural Sciences

Michella Ghassibe Sabbagh

Dr. Michella Ghassibe Sabbagh is an assistant professor of biology at LAU’s Department of Natural Sciences in Beirut. She joined LAU as a full-time faculty member in 2017.

Her research interests include deciphering the genetic basis of complex diseases such as type 2 diabetes and cancer. Her laboratory studies craniofacial anomalies and breast cancer cells in patients in order to identify and target the genes and the predisposing factors and unravel useful pathways for diagnosis and counseling. Her research on cleft lip and palate, as well as coronary artery disease has been published in peer-reviewed international journals and meetings and has been acknowledged internationally.

Publications

  1. Mustapha M, Salem N, Delague V, Chouery E, Ghassibeh M & al. Autosomal recessive non-syndromic hearing loss in the Lebanese population: Prevalence of the 30delG mutation and report of two novel mutations in the Connexin 26 (GJB2) gene. J Med Genet 2001;38:e3 
    IF=4.33; cited 82
  2. P Brouillard, L Boon, J Mulliken, O Enjolras, M Ghassibe & al. Mutations in a Novel Factor Glomulin are Responsible for Glomuvenous Malformations (“Glomangiomas”). Am J Hum Genet 2002;70(4):866-74
    IF=12.65; cited 188
  3. M Ghassibe & al. Six Families with Van der Woude and/or Popliteal Pterygium Syndrome: all with a mutation in the IRF6 gene. J Med Genet 2004;41:e15
    IF=4.33; cited 55
  4. P Brouillard, M Ghassibe & al. Four common glomulin mutations cause two thirds of glomuvenous malformations (“familial glomangiomas”): evidence for a founder effect. J Med Genet 2005;42 e13
    IF=4.33; cited 94
  5. M Ghassibe & al. Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population. Eur J Hum Genet 2005;13:1239-42
    IF=3.25; cited 87
  6. M Ghassibe & al. A Novel Loss of Function Mutation in the MSX2 Homeobox Gene in a Family with Foramina Parietalia Permagna. Eur J Pediatr 2006;165:734-735
    IF=1.14; cited 5
  7. Ghassibe M & al. Orofacial clefting: update on the role of genetics. B-ENT. 2006;2 Suppl 4:20-24
    IF=0.078; cited 14
  8. Ferreira de Lima RL, Hoper SA, Ghassibe M & al. Prevalence and nonrandom distribution of exonic mutations in interferon regulatory factor 6 in 307 families with Van der Woude syndrome and 37 families with popliteal pterygium syndrome. Genet Med 2009;11 (4):241-247
    IF=3.92; cited 65
  9. I Göhring, A Tagariello, S Endele, CC Stolt, M Ghassibé & al. Disruption of ST5 is associated with mental-retardation and multiple congenital anomalies. J Med Genet 2010;47:91-98
    IF=5.7; cited 9
  10. L Desmyter, M Ghassibe & al. IRF6 Screening of Syndromic and a priori Non-Syndromic Cleft Lip and Palate Patients: Identification of a New Type of Minor VWS Sign. Mol Syndromol 2010; 1(2): 67-74
    Cited 14
  11. Ghassibe-Sabbagh M & al. FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish. Am J Hum Genet 2011; 88:150-161
    IF=12.3; cited 34
  12.  Haber M, Youhanna S, Balanovsky O, Saade S, Martínez-Cruz, B, Ghassibe-Sabbagh M & al. mtDNA lineages reveal coronary artery disease associated structures in the Lebanese population. Ann Hum Genet 2012; 76(1):1-8
    IF=2.6; cited 8
  13. M Ghassibe-Sabbagh, S Saade, JB Cazier & al. Large scale association analysis identifies three susceptibility loci for coronary artery disease. PLoS ONE 2012; 6(12): e29427. doi:10.1371/journal.pone.0029427
    IF=4.6; cited 48
  14. M Ghassibe-Sabbagh & al. Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk. Atherosclerosis 2012; doi:10.1016/j.atherosclerosis.2012.02.035
    IF=4.08; cited 69
  15. J Hager, Y Kamatani, JB Cazier, S Youhanna, M Ghassibe-Sabbagh & al. Genome-wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis. PLoS ONE 2012; 2012; 7(6):e38663
    IF=4.6; cited 22
  16. Marc Haber, Daniel Platt, Maziar Ashrafian Bonab, Sonia Youhanna, David Soria-Hernanz, Begona Martinez-Cruz, Bouchra Douaihy, Michella Ghassibe-Sabbagh & al. Afghanistan’s ethnic groups share a Y-chromosomal heritage structured by historical events. PLoS ONE 2012; PLoS ONE 7(3): e34288. doi:10.1371/journal.pone.0034288
    IF=4.6; cited 29
  17. Badro DA, Douaihy B, Haber M, Youhanna SC, Salloum A, Ghassibe-Sabbagh M & al. Y-Chromosome and mtDNA Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations. PLoS ONE 2013;8(1):e54616
    IF=4.6; cited 21
  18. M Ghassibe-Sabbagh & al. Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population. Diabetol Metab Syndr 2014 Aug 21;6(1):89. doi: 10.1186/1758-5996-6-89.
    IF=2.50; cited 8
  19. Milane A, Abdallah J, Kanbar R, Khazen G, Ghassibe-Sabbagh M & al. Association of hypertension with coronary artery disease onset in the Lebanese population. Springerplus. 2014;16;3:533. 
  20. Ghassibe-Sabbagh M & al. T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility. Sci Rep. 2014;4:7351. doi: 10.1038/srep07351.
    IF=5.078; cited 5
  21. Platt DE, Ghassibe-Sabbagh M & al. Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography. J Thromb Thrombolysis 2015;39(1):15-22. 
    IF=2.039; cited 8
  22. Merhi M, Demirdjian S, Hariri E, Sabbah N, Youhanna S, Ghassibe-Sabbagh M & al. Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk. Inflamm Res. 2015;64(6):415-22.
    IF=2.143; cited 9
  23. Platt DE, Ghassibe-Sabbagh M & al. Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant. Ann Nutr Metab. 2016;68(1):1-11.
    IF=2.618; cited 4
  24. Milane A, Khazen G, Zeineddine N, Amro M, Masri L, Ghassibe-Sabbagh M & al. Association of coronary artery disease and chronic kidney disease in Lebanese population. Int J Clin Exp Med 2015; 15;8(9):15866-77.
    IF=1.277; cited 1

Academic degrees


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