The School of Arts & Sciences

Department of Computer Science & Mathematics

Joseph Rebehmed

Joseph Rebehmed is an assistant professor of Bioinformatics. He joined the Lebanese American University in January 2016 as a visiting assistant professor of Bioinformatics. He obtained a master’s degree in Bioinformatics and a PhD in Computational Chemistry and Informatics (with the highest level of distinction) from the University Paris Diderot, France.

Rebehmed has been working in R&D for many years. His main research interests include studying the relationships between the sequences, structures and functions of proteins, their evolutionary conservation and their alterations upon mutations leading to diseases. He also has a large expertise in the field of protein structure prediction and protein-ligand interactions in complexes of pharmaceutical interests with the main goal of designing new inhibitors and compounds that are more active and selective for a specific protein without having side effects. During his postdoc at the Medical School of the University of Michigan, USA, they predicted the best ligand-protein complex for CXCR4-CVX15, the most difficult target in the GPCR-dock 2010 worldwide experiment.

His current research focuses on enzyme design, detection of the interaction regions in proteins, as well as protein motion, dynamic and function.

Selected Publications

  1. “The respective roles of polar/non polar binary patterns and amino acid composition in protein regular secondary structures explored exhaustively using hydrophobic cluster analysis”, Joseph Rebehmed, Flavien Quintus, Jean-Paul Mornon, Isabelle Callebaut, in Proteins: Structure, Function and Bioinformatics, 2016.
  2. “Enzymatic Synthesis of Galatosylated S/T Derivatives by β-Galactosidase from E. coli”, Sooyoun Seo, Joseph Rebehmed, Alexandre G. de Brevern, Salwa Karboune, in International Journal of Molecular Sciences, 2015
  3. “Expanding the SRI family of domains: a common scaffold for RNA polymerase II PCTD binding”, Joseph Rebehmed, Patrick Revy, Guilhem Faure, Jean-Pierre de Villartay, Isabelle Callebaut, in FEBS letters, 2014
  4.  “Evolution study of the Baeyer-Villiger monooxygenases enzyme family: Functional importance of the highly conserved residues”, Joseph Rebehmed, Véronique Alphand, Véronique de Berardinis, Alexandre G. De Brevern, in Biochimie, 2013
  5. “Cis-trans isomerization of omega dihedrals in Proteins”, Pierrick Craveur, Agnel Praveen Joseph, Alexandre G. de Brevern, Joseph Rebehmed, in Amino Acids, 2013, 45(2): 279-89

Academic degrees

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